Clear cell odontogenic carcinoma ccoc is often considered as a rare tumor, first described by hansen in 1985. Clear cell odontogenic carcinoma report of two cases and. A case of clear cell odontogenic tumor with unusual histological features is presented. If clear cell carcinoma of endometrium is diagnosed early, then a surgical removal of the uterus where possible may help eliminate the cancer. About the kidneysevery person has 2 kidneys, which are located above the waist on both sides of the spine. Clear cell odontogenic carcinomaa rare case report. This article describes a case of clear cell odontogenic carcinoma ccoc in a 55yearold woman who presented such a tumor extending from the midline of the mandible to the right first molar. Clear cell odontogenic carcinoma is a rare neoplasm with very few cases reported in the literature. Clear cell odontogenic carcinoma and clear cell variant of mucoepidermoid carcinoma are rare and aggressive tumors that usually affect individuals in the fifth decade of life and have a.
A diagnosis of clear cell odontogenic carcinoma was entertained. The objectives of this article were to present 5 additional cases and to describe the clinical course, histologic spectrum, and immunocyto. This article describes a case of clear cell odontogenic carcinoma ccoc in a 55. Familial nonvhl clear cell renal cell carcinoma ccrcc is a hereditary condition that increases the risk of the clear cell type of renal cell carcinoma kidney cancer. The sqamous cell carcinoma should also be considered because of cytological pleomorphism and intercellular bridges2. Clear balloon cell malignant melanoma in malignant clear cell eccrine tumour, differential diagnosis trichilemmal carcinoma, there is absence of peripheral palisading and presence of acinar or ductal differentiation that can be demonstrated by. A 61yearold japanese man was admitted because of swelling of the left premolarmolar region of the mandible. Formerly known as clear cell odontogenic tumor, a locally aggressive benign tumor in the who classification of 1992, it was renamed ccoc and classified among malignant tumors after the revision of this classification in 2005. About 70% of patients are women with an age range from 1789 years. In 1992, who classified ccoc as benign odontogenic tumor however, in the who classification of 2005 it was considered to be a malignant tumor of odontogenic origin due to its aggressive nature, predilection to local recurrence, locoregional lymph node.
Think of that menu as a roadmap for this complete guide. Ccoc was initially known as clear cell odontogenic tumor or clear cell ameloblastoma. Biphasic variant of clear cell odontogenic carcinoma a case report. Clear cell odontogenic carcinoma it is a lowgrade carcinoma that is composed of cells that show uniform nuclei and clear cytoplasm. Background clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. It describes the epidemiologic, radiologic, and histopathologic features of presently known neoplasms and hamartomatous or tumorlike lesions arising from the toothforming structures, as well as a number of distinctive jaw lesions that must be distinguished from odontogenic tumors. Abstractclear cell odontogenic carcinomas are rare, aggressive tumours, most of which have been reported in the mandible of female patients.
Clearcell adenocarcinoma of the lung which is a type of clearcell carcinoma. The clear cell variant of ceot can be mistaken for clear cell odontogenic carcinoma, some metastatic carcinoma, like renal cell carcinoma, and some salivary gland tumors like mucoepidermoid carcinoma and acinic cell carcinoma2. Odontogenic cysts can give rise to a variety of neoplasms. Consequently, the name clear cell odontogenic carcinoma was thought to be more appropriate in view of the malignant potential manifested by this neoplastic lesion 2022.
This book greatly expands the body of knowledge in the field of odontogenic tumor pathology. Clear cell tumours are found in a number of organs. Vander poorten vl, balm aj, hilgers fj, tan ib, keus rb, hart aa. Clear cell odontogenic carcinoma is composed of irregular sheets of neoplastic epithelial cells immersed in a richly cellular, collagenous stroma. Primary clear cell carcinoma of minor salivary gland of. Primary intraosseous squamous cell carcinoma arising in. Clear cell is definitely more challenging than non clear cell but it has been gratifying to discover that there is a good size group of clear cell ovarian cancer women that are years out from their diagnosis. Definition of clear cell carcinoma nci dictionary of. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring predominantly in posterior mandible during 5th7th decades with a female predilection. Calcifying epithelial odontogenic tumor of the maxilla. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5 th 7 th decades and shows a female preponderance. Ghost cell odontogenic carcinoma gcoc was first described in detail as a malignant focus within a calcifying odontogenic cyst coc by ikemura et al.
It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases. It was then termed as clear cell odontogenic tumor considering its locally destructive nature. It is a potentially aggressive tumour, capable of recurring frequently, locally invasive, and with distant metastases. Pdf clear cell odontogenic carcinoma of the mandible. The tumor was surgically excised and has not recurred or metastasized 6 months after surgery. Also called clear cell adenocarcinoma and mesonephroma. It is known to occur mainly in the soft tissues and dermis. Clear cell adenocarcinoma definition of clear cell. A 70yearold woman presented with a large painful radiolucent mandibular lesion from the right canine to the left angle area through the midline. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor with predominance in the posterior mandible, usually occurring in the fifth to seventh decades of life, and being found more commonly in females. Maxillary clear cell odontogenic carcinoma a rare entity.
The majority of cases represent well differentiated keratinizing carcinoma 6,28. Mandibular clear cell odontogenic carcinoma springerlink. Clear cell odontogenic carcinoma archives of pathology. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor previously called clear cell ameloblastoma considered benign by who of 1992, but due to its high potential for regional spread and distant metastases, it was reclassified as malignant in 2005.
The tumor was surgically excised and has not recurred or. Clear cell odontogenic carcinoma ccoc is an infrequent tumor, which is aggressive by nature among the odontogenic tumors. Clear cell odontogenic tumora new histologic variant with aggressive potential. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the. Clearcell sarcoma is a rare form of cancer called sarcoma. Benign epithelial odontogenic neoplasm, clear cell variant may be composed primarily of clear cells occurs in posterior mandible, intraosseous location variably sized polyhedral eosinophilic epithelial cells with distinct cell borders are arranged in small. However, in general, clear cell carcinoma of endometrium has a poorer prognosis compared to endometrioid adenocarcinomas. Anytime i hear from a long term survivor i celebrate and feel. Clearcell odontogenic carcinoma with pulmonary metastases. Clear cell odontogenic carcinoma ccoc is a rare tumor of odontogenic origin. Clearcell carcinoma also known as clear cell adenocarcinoma and mesonephroma is an epithelial cell derived carcinoma characterized by the presence of clear cells observed during histological, diagnostic assessment. Pdf clear cell odontogenic carcinoma ccoc researchgate.
Pathogenesis and nomenclature of odontogenic carcinomas. Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. Even though it was once thought to no longer occur past the age of 30, it is still seen into the 40s and 50s. New term 85503 acinar cell carcinoma y excludes c61. Hyalinizing clear cell carcinoma of the hard palate the. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw described in 1985 for the first time by hansen 1. It was first described as a clinicopathological entity in 1985, and since then. Squamous cell carcinoma arising from an odontogenic. Histologically, the tumor was composed of clearcell areas and exhibited a squamous pattern with little nuclear pleomorphism similar to benign squamous. Clear cell odontogenic carcinoma of the mandible, journal. Clearcell odontogenic carcinoma ccoc is a rare neoplasm with malignant potential and unknown cytogenetic alterations. Clear cell carcinoma definition of clear cell carcinoma. Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma.
You will find some basic information about this disease and the parts of the body it may affect. Pdf odontogenic neoplasms of predominantly clear cells are unusual. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5th7th decades and shows a female preponderance. Objectives to report the clinicopathologic findings and followup. Clear cell carcinoma ccc also known as clear cell adenocarcinoma and hyalinizing clear cell carcinomahccc is one of the rarest tumors of the minor salivary glands and infrequently occurs at the base of the tongue. Clear cell odontogenic carcinoma mimicking a cystic lesion. Ccoc was classified as a malignant neoplasm of odontogenic origin by the who in 2005 as it exhibits an aggressive growth pattern, local. Clearcell adenocarcinoma of the vagina is a rare cancer, occurring in up to 10% of primary vaginal malignancies. Thus, it is important to have a list of em in ones head so one doesnt misdiagnose something. Here we report a clear cell odontogenic carcinoma of the maxilla in a 55year old male, which was predominantly composed of sheets of polygonal cells with clear cytoplasm, admixed with smaller. We describe the case of a 43yearold woman who presented with an unusual odontogenic epithelial tumor.
Here we report a case occurred in the posterior mandible of a 42 year old male patient which highlights the clinicopathologic features of ccoc that were confirmed by histopathologic. Biphasic variant of clear cell odontogenic carcinoma a. The treatment was mostly a radical surgical excision of the tumor with or without adjuvant radiotherapy or chemotherapy. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumour with female predilection occurring in the anterior region of the mandible with peak age incidence of 5th and 7th decade of life. They represent a diagnostic dilemma, and as a result, treatment strategies are. This form of cancer is classified as a rare cancer with an incidence of 4. Hyalinizing clear cell carcinoma of the hard palate volume 118 issue 5 tingkuang chao, chienchen tsai, shiouyu yeh, jonathan engkiat teh skip to main content accessibility help we use cookies to distinguish you from other users and to provide you with a. Metastatic clear cell adenocarcinoma of viscera example. To our knowledge, the mr imaging appearance of this entity has not been described. It is potentially aggressive, capable of frequent recurrences and locoregional and distant metastases. Clear cell odontogenic carcinoma ccoc is a rare neoplasm of the jaws and was first described by two separate groups of researchers, hansen et al. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor of the jaws, histologically characterized by the presence of. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw.
Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw which was first described as a clear cell odontogenic tumor in 1985 by hansen. Odontogenic tumor composed predominantly of clear cells is a rare neoplasm of the jaws that was initially designated as clear cell odontogenic tumor. Clearcell adenocarcinoma is a type of adenocarcinoma that shows clear cells types include. The clear cell odontogenic tumor is classified as a benign but locally invasive odontogenic tumor in the current world health organization classification for.
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